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Research Grand Rounds: Anti-Seizure Medications and the Developing Brain

Date Fri, Oct 2
Time 12: 00 PM - 1: 00 PM
Location Online


This month's Research Grand Rounds features Patrick A. Forcelli, PhD, who will discuss "Anti-Seizure Medications and the Developing Brain".

Dr. Forcelli is Associate Professor of Pharmacology & Physiology and of Neuroscience at Georgetown. For over a decade, his research has focused on preclinical models as tools to understand the impact of anti-seizure medications on brain development. Understanding therapeutic and toxic effects in these understudied patient groups (i.e., women, pregnant women, and neonates) is important clinically because these drugs are used both in pregnancy, to treat women with epilepsy, and in early life, to control neonatal seizures. Dr. Forcelli has found that even brief exposure to many common anti-seizure medications can permanently change brain structure and function with long-lasting effects on behavior. This work has been supported by NIH, foundations, and pharmaceutical companies and has implications for drug selection when treating women with epilepsy and neonates with seizures. His talk will highlight how pre-clinical research can inform and guide clinical investigations to improve outcomes for patients with epilepsy. In this sense, it is an exemplar of discipline-spanning translational research, with clear clinical applications in medicine, obstetrics, pediatrics, and neurology and in the design of studies which leverage preclinical models to advance clinical care by revealing mechanisms that could not be studied easily in humans.


Research Grand Rounds are sponsored by the Georgetown-Howard Universities Center for Clinical and Translational Science (GHUCCTS) and MedStar Health Research Institute to bring together our diverse clinical and research communities to share research that spans disciplines and stages of translation to improve individual and community health.

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