GHUCCTS

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Research Grand Rounds: An alternative to target-based drug discovery

Date Fri, Nov 6
Time 12: 00 PM - 1: 00 PM
Location Online


This month's Research Grand Rounds features Hazel H. Szeto, MD, PhD, who will discuss "An alternative to target-based drug discovery – Optimizing mitochondrial bioenergetics to combat noncommunicable diseases".

Dr. Szeto is director of research at the Social Profit Network Research Laboratory, professor emerita of Pharmacology at Weill Medical College of Cornell University, and scientific founder of Stealth Biotherapeutics. Her serendipitous discovery of a novel class of orally-active, widely-distributed mitochondrial-targeted peptide analogs with profound effects on mitochondrial structure and function has revealed bioenergetic mechanisms as key treatment targets in an almost-dizzying variety of disease models. Preclinical models suggest potential benefits in most all clinical domains, from ischemia-reperfusion injury to neurodegeneration, and including heart failure, muscle weakness and disuse atrophy, chemotherapy toxicities, diabetes, vision loss, orthopedic injury, acute kidney injury and progressive chronic kidney disease and a wide range of age-associated chronic diseases. Her research exemplifies widelycollaborative and discipline-spanning team science focused on translating basic discoveries to therapeutic impact while revealing new pathophysiological mechanisms and basic biology.


Research Grand Rounds are sponsored by the Georgetown-Howard Universities Center for Clinical and Translational Science (GHUCCTS) and MedStar Health Research Institute to bring together our diverse clinical and research communities to share research that spans disciplines and stages of translation to improve individual and community health.

Upcoming Events
Dec 03
Dean's Seminar Series: Kandice Tanner, PhD  Dec 03, 2020  4: 00 PM - 5: 00 PM  Online
The Georgetown University Medical Center (GUMC) Office of the Dean for Research is proud to present the Dean's Seminar Series. This seminar features Kandice Tanner, PhD, Laboratory for Cell Biology, NCI, NIH.
This month's Research Grand Rounds features Moshe Levi, MD, Interim Dean for Research and Professor of Biochemistry, Molecular and Cellular Biology at Georgetown University. Dr. Levi will discuss "Role of bile acid regulated receptors in the pathogenesis and treatment of NASH and obesity related kidney disease".
Dec 09
Optimizing Sleep During COVID-19  Dec 09, 2020  11: 00 AM - 12: 00 PM  Online
The Howard University COVID-19 Recovery & Resiliency Project (Howard R&R Project) is pleased to present a series of educational webinars to support the health and wellness of our frontline health care professionals and our DC residents. This webinar features Thomas Mellman, MD & Tyish Hall Brown, PhD, MHS, both from Howard University. Dr. Mellman and Dr. Hall Brown will discuss "Optimizing Sleep During COVID-19".
Dec 10
TBS Workshop: Scholar Presentations  Dec 10, 2020  5: 30 PM - 7: 30 PM  Online
This week's Translational Biomedical Science (TBS) Program workshop features scholar presentations from Sean Carey, PhD candidate; Chaz Hinzman, PhD candidate; and Sarra Djemil, PhD.
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