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Research Grand Rounds: An alternative to target-based drug discovery

Date Fri, Nov 6
Time 12: 00 PM - 1: 00 PM
Location Online


This month's Research Grand Rounds features Hazel H. Szeto, MD, PhD, who will discuss "An alternative to target-based drug discovery – Optimizing mitochondrial bioenergetics to combat noncommunicable diseases".

Dr. Szeto is director of research at the Social Profit Network Research Laboratory, professor emerita of Pharmacology at Weill Medical College of Cornell University, and scientific founder of Stealth Biotherapeutics. Her serendipitous discovery of a novel class of orally-active, widely-distributed mitochondrial-targeted peptide analogs with profound effects on mitochondrial structure and function has revealed bioenergetic mechanisms as key treatment targets in an almost-dizzying variety of disease models. Preclinical models suggest potential benefits in most all clinical domains, from ischemia-reperfusion injury to neurodegeneration, and including heart failure, muscle weakness and disuse atrophy, chemotherapy toxicities, diabetes, vision loss, orthopedic injury, acute kidney injury and progressive chronic kidney disease and a wide range of age-associated chronic diseases. Her research exemplifies widelycollaborative and discipline-spanning team science focused on translating basic discoveries to therapeutic impact while revealing new pathophysiological mechanisms and basic biology.


Research Grand Rounds are sponsored by the Georgetown-Howard Universities Center for Clinical and Translational Science (GHUCCTS) and MedStar Health Research Institute to bring together our diverse clinical and research communities to share research that spans disciplines and stages of translation to improve individual and community health.

Upcoming Events
Mar 11
RCR: Rigor & Responsibility in the time of COVID  Mar 11, 2021  5: 30 PM - 7: 30 PM  Zoom
Kathryn Sandberg, PhD, Georgetown University will present "Rigor & Responsibility in the time of COVID" as a part of the Translational Biomedical Science (TBS) Responsible Conduct of Research (RCR) Series.
Mar 18
Master's in Clinical & Translational Research Info Session  Mar 18, 2021  10: 30 AM - 11: 00 AM  Zoom
Join this info session to learn more about the Georgetown University Master's in Clinical and Translation Research. Program staff will provide an overview of the Master's in Clinical and Translational Research Program, including the admissions process, careers in Clinical and Translational Research, and other frequently asked questions.
This month's MHRI-GHUCCTS Monthly Statistical Seminar Series features Dr. Paul Kolm, Associate Director in the Department of Biostatistics and Biomedical Informatics at MedStar Health Research Institute. Dr. Kolm will discuss "Propensity Score Analysis of Non-randomized Studies".
Mar 23
Diabetes Alert Day! Managing Diabetic Kidney Disease  Mar 23, 2021  6: 00 PM - 7: 00 PM  Zoom
GHUCCTS in the (Virtual) Community aims to promote clinical research awareness, diversity in research, and community engaged research through virtual outreach efforts that will be held monthly. Our February session will cover "Diabetes Alert Day! Managing Diabetic Kidney Disease".
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