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Protein Homeostasis in Neurons: how protein synthesis and degradation are regulated in healthy and diseased brain

Date Fri, Oct 8
Time 10: 00 AM - 1: 00 PM
Location Zoom

GHUCCTS invites you to Dr. Haiyan He's symposium "Protein Homeostasis in Neurons: how protein synthesis and degradation are regulated in healthy and diseased brain" featuring keynote speaker Dr. Erin Schuman and panelists Dr. Seth Margolis, Dr. Clarissa Waites, and Dr. Charbel Moussa.

Abstract: This mini-symposium will feature a keynote lecture by Dr. Schuman on the logistics of protein supply at synapses and lead into a series of short talks that focus on different aspects of new advances in our understanding of the regulation of protein homeostasis in healthy and diseased brain.

Headshot of Dr. Erin SchumanKEYNOTE SPEAKER: Erin Schuman, PhD, Dr. Schuman is an elected member of Academia Europaea and US National Academy of Science. Her lab has pioneered in the studies of molecular and cell biological processes that control protein synthesis and degradation in neurons. In recent years, her lab has advanced a slew of new techniques to examine the regulation of protein homeostasis in neurons and synapses with unprecedented spatial and temporal resolution.

Headshot of GHUCCTS KL2 Scholar Dr. Haiyan HeKL2 SCHOLAR: Haiyan He, PhD, Assistant Professor in the Department of Biology at Georgetown University will work on “A novel protein-degradation-based mechanism for fast homeostatic plasticity and its implication in neurodegenerative diseases.” Dr. He is investigating the in vivo function of a newly discovered neuronal membrane-associated proteasome as a fast-homeostatic mechanism and its potential link to neurodegenerative diseases. She is mentored by Dr. Seth Margolis from the Departments of Biological Chemistry and Neuroscience at Johns Hopkins University School of Medicine with co-mentorship by Drs. Dan Pak, Brent Harris, and Kathy Maguire-Zeiss, at Georgetown University Medical Center.

PANELISTS:

  • Seth Margolis, PhD, Johns Hopkins University
    • "The Neuronal Membrane Proteasome (NMP): A Modulator of Nervous System Signaling"
  • Clarissa Waites, PhD, Columbia University
    • "ESCRT service: Regulation of synaptic vesicle protein degradation by the endolysosomal pathway"
  • Charbel Moussa, MBBS, PhD, Georgetown University Medical Center
    • "Protein Handling and Blood Brain Barrier in Individuals Diagnosed with Parkinson's Disease with Dementia"
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