The Georgetown University Medical Center (GUMC) Office of the Dean for Research is proud to present the Dean's Seminar Series. This seminar features Marc Reitman, MD, PhD, Senior Investigator, National Institute of Diabetes and Digestive and Kidney Diseases at NIH. Dr. Reitman will discuss "Regulation of Energy Homeostasis and Obesity: Using Mice to Understand Human Physiology".

ABSTRACT: Obesity prevalence is 38% in the United States and current pharmacotherapies are inadequate. Most obesity drugs have been identified via fortuitous observations and not developed rationally from the knowledge of physiology. We use mice to elucidate the biology of energy homeostasis. One area of investigation is on how to use mice to better model human biology. This led to a focus on thermal biology and brown adipose tissue (BAT), a major mouse/human difference. We are also investigating the neural control of energy expenditure and food intake, with a focus on the neurons expressing the marker BRS3. BRS3 neurons in one brain region (PVH) control food intake, while others (DMH, POA) control energy expenditure.

Accreditation: In support of improving patient care, this activity has been planned and implemented by MedStar Health and Georgetown University Medical Center. MedStar Health is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

Credit Designation: MedStar Health designates this live activity for a maximum of 1.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.