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Dean's Seminar Series: Antiviral innate immune defense mechanisms and viral escape

Date Thu, Feb 11
Time 4: 00 PM - 5: 00 PM
Location Zoom


Headshot of Dr Michael Gack wearing a beige blazer and pearl earringsThe Georgetown University Medical Center (GUMC) Office of the Dean for Research is proud to present the Dean's Seminar Series. This seminar features Michaela Gack, PhD, The Arthur and Marylin Levitt Endowed Chair & Scientific Director of the Florida Research & Innovation Center at the Cleveland Clinic Florida. Dr. Gack will discuss "Antiviral innate immune defense mechanisms and viral escape".

ABSTRACT: Accurate sensing of viral pathogens by innate immune sensor proteins is critical for mounting an effective antiviral response in both non-immune and immune cells. These sensors recognize conserved pathogen-associated molecular patterns (PAMPs) and subsequently activate signaling that results in the production of many antiviral molecules, including type I interferons (IFNs).

It has become evident that intracellular viral RNA sensors of the RIG-I-like receptor (RLR) family are important sensors for many RNA viruses including coronaviruses and influenza viruses. As a consequence, many RNA viruses manipulate the sensing and/or signaling activity of RLRs to escape detection by the immune surveillance apparatus. For example, our previous work demonstrated that influenza virus and measles virus manipulate specific posttranslational modifications – Lys63-linked ubiquitination and phosphorylation – of RLRs to evade innate immunity. We also have recently reported that dengue virus and related mosquito-transmitted flaviviruses inhibit the translocation of RLRs to mitochondria, impeding the interaction of RLRs with the adaptor protein MAVS.


Accreditation: In support of improving patient care, this activity has been planned and implemented by MedStar Health and Georgetown University Medical Center. MedStar Health is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

Credit Designation: MedStar Health designates this live activity for a maximum of 1.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

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