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Clinical Proteomics for Diagnostics and Precision Medicine: Tumor Heterogeneity and Treatment Response

Date Wed, Nov 20
Time 09: 00 AM - 12: 30 PM
Location Georgetown University
4000 Reservoir Road NW, Building D, Warwick Evans Conference Room, Washington, DC, 20007
Contact Rebecca Ho
202-687-2103


GHUCCTS invites you to KL2 Scholar Dr. Chukwuemeka Ihemelandu's symposium "Clinical Proteomics for Diagnostics and Precision Medicine: Tumor Heterogeneity and Treatment Response" featuring keynote speaker Dr. Emanuel F. Petricoin and panelists Dr. Kevin Cleary, Dr. Martin J. Schnermann, and Dr. Stanley Fricke.

Space is limited - please RSVP. Lunch will be provided. Zoom web conferencing will be available for those who are unable to join us in-person. 

ABSTRACT: While DNA is the information archive, the proteins do the work of the cell and constitute most of the cellular machinery. Functionally, nearly all of the FDA-approved drugs work by modulating protein expression and/or protein activity/location. Moreover, many of the biomarkers that are measured in the clinic for routine disease detection to more esoteric testing are proteins. This backdrop provides context to the exploding field of proteomics in the post-genome era; however, proteomics is constrained by technological and biochemical limitations: lack of a PCR-equivalent technology to amplify low-abundance proteins and relative analytical insensitivity of mass spectrometry, lability of proteins in vivo, and massive dynamic range and complexity of the human proteome. To help deliver on the promise of clinical proteomics, new technologies have been developed that can amplify low-abundance proteins for discovery and point-of-care testing. Likewise, new types of protein arrays for precision medicine-based applica ions have been developed. Case studies of these technologies, as applied to the bedside, will be presented for colon cancer to emphasize the clinical impact that could be achieved as well as highlight the global potential for incorporation into the early detection and precision medicine workflow.

KEYNOTE SPEAKER: Dr. Emanuel F Petricoin has been the Co-Director of the Center for Applied Proteomics and Molecular Medicine (CAPMM) at George Mason University since 2005, where he is a University Professor. Prior to this position, he served as Co-Director of the FDA-NCI Clinical Proteomics Program from 2001-2005, and a Senior Investigator within the Center for Biologics Evaluation and Research at the US Food and Drug Administration from 1993-2005. The focus of the CAPMM is the invention and use of proteomics technologies for personalized therapy, molecular diagnostics and biomarker discovery. He is a co-founder of 4 life science companies. Dr. Petricoin’s expertise includes precision medicine, proteomics and protein biomarkers, cell signaling, molecular diagnostic assay development, biologics and cellular therapeutics regulation, as well as artificial intelligence-based algorithms.

Headshot of KL2 Scholar Dr. Chukwuemeka Ihemelandu. He is smiling and wearing glasses.KL2 SCHOLAR: Dr. Chukwuemeka Ihemelandu is an Associate Professor of surgical oncology in the Department of Surgery at Georgetown University Medical Center and a 2018 GHUCCTS KL2 Scholar. Dr. Ihemelandu’s research focuses on understanding
how identification of different tumor phenotypes and tumor microenvironments could be used to develop improved methods for early cancer detection, diagnosis, and prognosis. His work on in vivo imaging methods that allow the reliable and quantifiable identification of molecular signatures and architectures of tumors, the evaluation of genetic evolution of tumor cells the other cell types in the tumor microenvironment that contribute to the observed and changing landscapes of tumor heterogeneity, and the real-time assessment of cancer treatment response have the potential to significantly improve cancer detection, diagnoses, treatment response and lead to personalized clinical cancer care.

PANELISTS:

Kevin Cleary, PhD    Martin J. Schnermann, PhD    Stanley Fricke, NucE, PhD
Scientific Lead of the Sheikh Zayed
Institute for Pediatric Surgical
Innovation at Children’s National
Medical Center
Senior Investigator, Chemical Biology
Laboratory; Head, Organic Synthesis
Section at the Center for Cancer
Research - National Cancer Institute

Director of Medical Physics
Center for Translational Imaging
Departments of Radiology and
Oncology, Georgetown University
Medical Center


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